Our lab is interested to understand how cell death and injury occur in the very early stages of Alzheimer's disease (AD) and multiple sclerosis (MS). Therefore, we use a wide variety of methods, including multi-omics, genetic engineering, and microscopy to delineate how neurons and glia cells communicate and die in AD and MS.

Alzheimer's disease (AD) and multiple sclerosis (MS) are among the most prevalent neurological diseases worldwide. Therefore, people with AD and MS commonly have other diseases that decisively shape the disease courses. We are interested to delineate resilience and vulnerability to AD and MS pathologies and neurodegeneration by analyzing co-pathologies like cardiovascular diseases or infections in AD and MS.

Our lab is participating in a local neurological biobank with blood, cerebrospinal fluid, brain biopsies and autopsy tissues. Biobanking is a central step to translate our findings from basic research to applications in people with AD or MS. To facilitate reproducibility, we are collaborating with large cohorts and biobanks worldwide.